Novel platelet-neutrophil interaction via activated αIIbβ3 mediates NETosis under flow
Abstract
null Platelet-leukocyte interactions are important for innate immune responses, but also contribute to the pathogenesis of thrombotic disorders, such as deep vein thrombosis. How these interactions are manifest and how they influence leukocyte function remains poorly understood. Here, we demonstrate that binding to von Willebrand factor under flow through glycoprotein Ibα ‘primes’ platelets resulting in intracellular Ca2+ release and αIIbβ3...
Paper Details
Title
Novel platelet-neutrophil interaction via activated αIIbβ3 mediates NETosis under flow
Published Date
Jul 21, 2018
Journal
Pages
373670
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