Modeling white matter tract integrity in aging with diffusional kurtosis imaging

Volume: 70, Pages: 265 - 275
Published: Oct 1, 2018
Abstract
Myelin breakdown and neural fiber loss occur in aging. This study used white matter tract integrity metrics derived from biophysical modeling using Diffusional Kurtosis Imaging to assess loss of myelin (i.e., extraaxonal diffusivity, radial direction, De,⊥) and axonal density (i.e., axonal water fraction) in cognitively unimpaired older adults. Tract-based spatial statistics and region of interest analyses sought to identify ontogenic...
Paper Details
Title
Modeling white matter tract integrity in aging with diffusional kurtosis imaging
Published Date
Oct 1, 2018
Volume
70
Pages
265 - 275
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