Single-cell transcriptome analysis of lineage diversity in high-grade glioma.
Abstract
Despite extensive molecular characterization, we lack a comprehensive understanding of lineage identity, differentiation, and proliferation in high-grade gliomas (HGGs). We sampled the cellular milieu of HGGs by profiling dissociated human surgical specimens with a high-density microwell system for massively parallel single-cell RNA-Seq. We analyzed the resulting profiles to identify subpopulations of both HGG and microenvironmental cells and...
Paper Details
Title
Single-cell transcriptome analysis of lineage diversity in high-grade glioma.
Published Date
Jul 24, 2018
Journal
Volume
10
Issue
1
Pages
57 - 57
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Notes
History