Formulary

Gene

Intensive care medicine

Ceftazidime/avibactam

Carbapenem-resistant enterobacteriaceae

Carbapenem

Ceftazidime

Avibactam

Pseudomonas aeruginosa

Enterobacteriaceae

Colistin

Meropenem

Antibiotics

Bacteria

Genetics

Escherichia coli

Biochemistry

Medicine

Biology

Microbiology

Antibiotic resistance

Pharmacology

Clinical Infectious Diseases

Ceftazidime/avibactam and meropenem/vaborbactam are changing the management of invasive infections due to carbapenem-resistant Enterobacteriaceae (CRE), leading to higher rates of clinical cure, decreased mortality, and decreased rates of acute kidney injury compared with colistin-based regimens. However, these 2 agents are not interchangeable with regard to management of CRE infections, and clinicians need to be aware of their differences. This review focuses on differences in the in vitro activity of these agents as a function of mechanism of carbapenem resistance, the clinical data supporting their superiority over colistin-based therapy, and the differences between agents with regard to propensity for selection of resistance. Furthermore, considerations and recommendations for hospital formularies and antibiotic stewardship programs regarding positioning of these agents are discussed.

Ceftazidime/Avibactam, Meropenem/Vaborbactam, or Both? Clinical and Formulary Considerations