On the determination of planning target margins due to motion for mice lung tumours using a four-dimensional MOBY phantom

This work aims to analyse the effect of respiratory motion on optimal irradiation margins for murine lung tumour models.Four-dimensional mathematical phantoms with different lung tumour locations affected by respiratory motion were created. Two extreme breathing curves were adopted and divided into time-points. Each time-point was loaded in a treatment planning system and Monte Carlo (MC) dose calculations were performed for a 360° arc plan. A...