Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
Abstract
The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened cellular glucose uptake in consort with increased flux through glycolysis, followed by the preferential conversion of glycolytic pyruvate...
Paper Details
Title
Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
Published Date
Jul 16, 2018
Journal
Volume
17
Issue
1
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