Genome-wide identification of transcription factors that are critical to non-small cell lung cancer
Abstract
To systematically unveil transcription factors (TFs) that are critical to lung carcinogenesis, here we conducted a genome-wide lethality screening in non-small cell lung cancer (NSCLC) cells and reported that among the 1530 TFs tested, 21 genes were required for NSCLC cell proliferation and were negatively or positively associated with overall survival (OS) of patients with NSCLC. These included 11 potential tumor suppressing genes (AFF3, AhR,...
Paper Details
Title
Genome-wide identification of transcription factors that are critical to non-small cell lung cancer
Published Date
Oct 1, 2018
Journal
Volume
434
Pages
132 - 143
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