Photodynamic therapy in hypoxia: Near-infrared-sensitive, self-supported, oxygen generation nano-platform enabled by upconverting nanoparticles

Photodynamic therapy (PDT) shows great potential in anti-cancer therapy. The efficiency of PDT is greatly limited by the hypoxia environment in tumors. However, current methods developed to conquer this problem did not accurately produce oxygen for PDT of a certain amount and in a certain position, which could bring a potential risk to normal cells and tissues. Here, upconverting nanoparticles (UCNPs) and gold oxide (Au2O3) were integrated to...