Reducing protein oxidation reverses lung fibrosis

Volume: 24, Issue: 8, Pages: 1128 - 1135
Published: Jul 9, 2018
Abstract
Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the lung, leading to chronically impaired gas exchange and death1-3. Oxidative stress is believed to be critical in this disease pathogenesis4-6, although the exact mechanisms remain enigmatic. Protein S-glutathionylation (PSSG) is a post-translational modification of proteins that can be reversed by glutaredoxin-1 (GLRX)7. It remains unknown whether GLRX and...
Paper Details
Title
Reducing protein oxidation reverses lung fibrosis
Published Date
Jul 9, 2018
Volume
24
Issue
8
Pages
1128 - 1135
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