Internal medicine

Biotechnology

In vivo

Virus

Respiratory disease

Influenza A virus

Bronchus

Influenza A virus subtype H5N1

Biology

Virology

Immunology

Ex vivo

Lung

Organoid

Tissue tropism

Cell biology

Tropism

Medicine

The Lancet Respiratory Medicine

Human airway organoid cultures provided results that were comparable to those observed in human ex-vivo bronchus cultures, and thus provide an alternative physiologically relevant experimental model for investigating virus tropism and replication competence that could be used to assess the pandemic threat of animal influenza viruses.

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures