Staphylococcus aureus haem biosynthesis and acquisition pathways are linked through haem monooxygenase IsdG

Summary Haem is an essential cofactor in central metabolic pathways in the vast majority of living systems. Prokaryotes acquire haem via haem biosynthesis pathways, and some also utilize haem uptake systems, yet it remains unclear how they balance haem requirements with the paradox that free haem is toxic. Here, using the model pathogen Staphylococcus aureus , we report that IsdG, one of two haem oxygenase enzymes in the haem uptake system,...