Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells
Abstract
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression. Therefore, understanding what activates ERα is critical for cancer treatment in particular and cell biology in general. Using biochemical approaches and superresolution microscopy, we show that estrogen drives membrane ERα into endosomes in breast cancer cells and that its fate is determined by...
Paper Details
Title
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells
Published Date
Jul 6, 2018
Journal
Volume
217
Issue
8
Pages
2777 - 2798
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Notes
History