Evaluating the potential role of pleiotropy in Mendelian randomization studies.
Abstract
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ('vertical pleiotropy'), then Mendelian randomization (MR) can be used to estimate the causal influence between the traits. Of prime focus among the many limitations to MR is the unprovable...
Paper Details
Title
Evaluating the potential role of pleiotropy in Mendelian randomization studies.
Published Date
Aug 1, 2018
Journal
Volume
27
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