Original paper

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

Volume: 128, Issue: 9, Pages: 3976 - 3990
Published: Aug 13, 2018
Abstract
Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive rise in neuropilin-1 (NRP1) expression, which is crucial for the onset of acquired resistance to therapy. Moreover, NRP1 levels dictated the efficacy of MET oncogene...
Paper Details
Title
Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies
Published Date
Aug 13, 2018
Volume
128
Issue
9
Pages
3976 - 3990
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