The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence
Abstract
Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of...
Paper Details
Title
The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence
Published Date
Jul 1, 2018
Journal
Volume
38
Issue
7
Pages
3817 - 3824
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