GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer

Volume: 37, Issue: 44, Pages: 5873 - 5886
Published: Jul 4, 2018
Abstract
Estrogenic hormone replacement therapy increases the risk of developing ovarian cancer, and estrogen promotes tumour initiation and growth in mouse models of this disease. GREB1 (Growth regulation by estrogen in breast cancer 1) is an ESR1 (estrogen receptor 1)-upregulated protein which may mediate estrogen action. GREB1 knockdown prevents hormone-driven proliferation of several breast and prostate cancer cell lines and prolongs survival of mice...
Paper Details
Title
GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer
Published Date
Jul 4, 2018
Journal
Volume
37
Issue
44
Pages
5873 - 5886
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