A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination

Allen Zinkle; Moosa Mohammadi

doi:https://doi.org/10.12688/f1000research.14143.1

doi.org/10.12688/f1000research.14143.1

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination

,

Volume: 7, Pages: 872 - 872

Published: Jun 21, 2018

Abstract

Upon ligand engagement, the single-pass transmembrane receptor tyrosine kinases (RTKs) dimerize to transmit qualitatively and quantitatively different intracellular signals that alter the transcriptional landscape and thereby determine the cellular response. The molecular mechanisms underlying these fundamental events are not well understood. Considering recent insights into the structural biology of fibroblast growth factor signaling, we...

Paper Fields

Paper Details

Title

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination

DOI

doi.org/10.12688/f1000research.14143.1

Published Date

Jun 21, 2018

Journal

F1000Research

Volume

7

Pages

872 - 872

Citation AnalysisPro

You’ll need to upgrade your plan to Pro

Looking to understand the true influence of a researcher’s work across journals & affiliations?

Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.

Learn more

Notes

History