Selective modification of fluciclovine ( 18 F) transport in prostate carcinoma xenografts

Volume: 50, Issue: 9, Pages: 1301 - 1305
Published: Jun 15, 2018
Abstract
We investigated if previously demonstrated inhibition of fluciclovine (18F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts,...
Paper Details
Title
Selective modification of fluciclovine ( 18 F) transport in prostate carcinoma xenografts
Published Date
Jun 15, 2018
Volume
50
Issue
9
Pages
1301 - 1305
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