Review paper

Mechanisms of protein toxicity in neurodegenerative diseases

Volume: 75, Issue: 17, Pages: 3159 - 3180
Published: Jun 12, 2018
Abstract
Protein toxicity can be defined as all the pathological changes that ensue from accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most neurodegenerative diseases manifest protein toxicity as one of their key pathogenic mechanisms, the details of which remain unclear. By systematically deconstructing the nature of toxic proteins, we aim to elucidate and illuminate some of the key mechanisms of protein toxicity...
Paper Details
Title
Mechanisms of protein toxicity in neurodegenerative diseases
Published Date
Jun 12, 2018
Volume
75
Issue
17
Pages
3159 - 3180
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