Progressive methylation of POU5F1 regulatory regions during blastocyst development
Abstract
The POU5F1 gene encodes one of the 'core' transcription factors necessary to establish and maintain pluripotency in mammals. Its function depends on its precise level of expression, so its transcription has to be tightly regulated. To date, few conserved functional elements have been identified in its 5' regulatory region: a distal and a proximal enhancer, and a minimal promoter, epigenetic modifications of which interfere with POU5F1 expression...
Paper Details
Title
Progressive methylation of POU5F1 regulatory regions during blastocyst development
Published Date
Aug 1, 2018
Journal
Volume
156
Issue
2
Pages
145 - 161
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