Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
Abstract
The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in the vascular smooth muscle cells (VSMCs) of the arterial wall. Angiotensin II (Ang II) amplifies TGF-β1 activation in the VSMCs of the arterial wall with aging. In this study, we hypothesized that a reduced expression of the protein vasorin plays a contributory role in magnifying Ang...
Paper Details
Title
Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
Published Date
Jun 5, 2018
Journal
Volume
9
Issue
43
Pages
27117 - 27132
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