Characterization of subgroup J avian Leukosis virus isolated from Chinese indigenous chickens

Published on Feb 13, 2018in Virology Journal4.099
路 DOI :10.1186/S12985-018-0947-1
Fanfeng Meng11
Estimated H-index: 11
(SDAU: Shandong Agricultural University),
Qiuchen Li4
Estimated H-index: 4
(SDAU: Shandong Agricultural University)
+ 5 AuthorsPeng Zhao16
Estimated H-index: 16
(SDAU: Shandong Agricultural University)
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Abstract
Background In spite of the purification of the laying hens and broilers of avian leukosis virus (ALV) has made remarkable achievements, the infection of ALV was still serious in Chinese indigenous chickens.
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References26
Newest
#1Fanfeng Meng (SDAU: Shandong Agricultural University)H-Index: 11
#2Xue Li (SDAU: Shandong Agricultural University)H-Index: 3
Last. Zhihao Liu (SDAU: Shandong Agricultural University)H-Index: 1
view all 13 authors...
: The genomic diversity of Avian leukosis virus subgroup J (ALV-J) was investigated in an experimentally infected chicken. ALV-J variants in tissues from four different organs of the same bird were re-isolated in DF-1 cells, and their gp85 gene was amplified and cloned. Ten clones from each organ were sequenced and compared with the original inoculum strain, NX0101. The minimum homology of each organ ranged from 96.7 to 97.6%, and the lowest homology between organs was only 94.9%, which was much...
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#1Yang Li (SDAU: Shandong Agricultural University)H-Index: 13
#2Jiayuan Fu (SDAU: Shandong Agricultural University)H-Index: 5
Last. Peng Zhao (SDAU: Shandong Agricultural University)H-Index: 16
view all 8 authors...
Abstract To compare the genetic diversity and quasispecies evolution of avian leukosis virus (ALV) among different individuals, 5 chickens, raised in Shandong Provice of China, were randomly selected from a local chicken flock associated with serious tumor cases. Blood samples were collected and inoculated into chicken embryo fibroblast and DF-1 cell lines for virus isolation and identification, respectively, of Marek's disease virus (MDV), reticuloendotheliosis virus (REV), and ALV. Five strain...
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#1Wencheng Lin (SCAU: South China Agricultural University)H-Index: 10
#2Xinjian Li (SCAU: South China Agricultural University)H-Index: 5
Last. Qingmei Xie (SCAU: South China Agricultural University)H-Index: 25
view all 9 authors...
Members of avian leukosis virus subgroup J (ALV-J) cause various diseases associated with tumor formation and decreased fertility, resulting in major economic losses in the poultry industry worldwide. To assess the status of ALV-J infection in meat-type chickens in southern China, the molecular epidemiology of ALV-J strains was investigated. A total of 265 clinical samples collected from southern China from 2013 to 2014 were investigated in this study for the presence of ALV-J, which resulted in...
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#1Xinjian Li (SCAU: South China Agricultural University)H-Index: 5
#2Wencheng LinH-Index: 10
Last. Qingmei XieH-Index: 25
view all 12 authors...
Avian leukosis virus (ALV) causes high mortality associated with tumor formation and decreased fertility, and results in major economic losses in the poultry industry worldwide. Recently, a putative novel ALV subgroup virus named ALV-K was observed in Chinese local chickens. In this study, a novel ALV strain named GD14LZ was isolated from a Chinese local yellow broiler in 2014. The proviral genome was sequenced and phylogenetically analyzed. The replication ability and pathogenicity of this viru...
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#1Mark茅ta Reini拧ov谩 (CAS: Academy of Sciences of the Czech Republic)H-Index: 8
#2Ji艡铆 Plach媒 (CAS: Academy of Sciences of the Czech Republic)H-Index: 17
Last. Ji艡铆 Hejnar (CAS: Academy of Sciences of the Czech Republic)H-Index: 19
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J subgroup avian leukosis virus (ALV-J) infects domestic chicken, jungle fowl, and turkey and enters the host cell through a receptor encoded by tvj locus and identified as Na+/H+ exchanger 1 (NHE1). The resistance to ALV-J in a great majority of examined galliform species was explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of NHE1, and genetic polymorphisms around this site predict the susceptibility or resistance of a given species or indiv...
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#1Ning Cui (SDAU: Shandong Agricultural University)H-Index: 9
#2Shuai Su (SDAU: Shandong Agricultural University)H-Index: 9
Last. Zhizhong Cui (SDAU: Shandong Agricultural University)H-Index: 20
view all 5 authors...
The strain JS11C1, a member of a putative new subgroup of avian leukosis virus (ALV) that is different from all six known subgroups from chickens based on Gp85 amino acid sequence comparison, was isolated from Chinese native chicken breeds in 2012. In order to further study the genome structure, biological characteristics, and the evolutionary relationship of the virus with others of known subgroups from infected chickens, we determined the complete genome sequence, constructed an infectious clo...
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#1YaQing Mao (CAU: China Agricultural University)H-Index: 1
#2Weihua Li (SDAU: Shandong Agricultural University)H-Index: 6
Last. Peng Zhao (SDAU: Shandong Agricultural University)H-Index: 16
view all 5 authors...
Blood samples were collected from a local strain of chickens associated with serious tumor cases in Shandong Province. The samples were inoculated into chicken embryo fibroblast and DF-1 cells for virus isolation and identification, respectively. The inoculated cells were screened for three common chicken tumor viruses. Nine strains of avian leukosis virus subgroup J (ALV-J) were identified, and were designated LY1201-LY1209. The env gene from the LY1201 strain was amplified and cloned. All nine...
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The present review is aimed at the non-specialist reader and is one of a number being written on important diseases of poultry to celebrate the 40th anniversary of the birth of Avian Pathology, the journal of the World Veterinary Poultry Association. The diseases of the avian leukosis complex have a number of features of distinction. They were the first neoplastic diseases in any species to be shown, 100 years ago, to be transmissible and caused by viruses, and have consequently been studied ext...
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#1Hanzhang Lai (SCAU: South China Agricultural University)H-Index: 3
#2Henan Zhang (SCAU: South China Agricultural University)H-Index: 3
Last. Ming Liao (SCAU: South China Agricultural University)H-Index: 34
view all 10 authors...
Subgroup J avian leukosis virus (ALV-J), first isolated in 1989, predominantly causes myeloid leukosis (ML) in meat-type or egg-type chicken. Since 2006, the clinical cases of hemangioma rather than ML in commercial layer flocks associated with ALV-J have been reported, but it was still not clear whether the novel oncogenic ALV-J had emerged. We characterized SCAU-HN06 isolate of ALV-J from hemangioma in commercial Roman layers through animal experiment and full-length proviral genome sequence a...
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#1Minda M. McNally (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#2Karl J. Wahlin (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
Last. M. Valeria Canto-Soler (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 11
view all 3 authors...
Background The use of Specific Pathogen Free (SPF) eggs in combination with RCAS retrovirus, a member of the Avian Sarcoma-Leukosis Virus (ASLV) family, is of standard practice to study gene function and development. SPF eggs are certified free of infection by specific pathogen viruses of either exogenous or endogenous origin, including those belonging to the ASLV family. Based on this, SPF embryos are considered to be free of ASLV viral protein expression, and consequently in developmental rese...
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Cited By15
Newest
#1Yuan Chen (Huizhou University)
#2Hong-Wei Li (Huizhou University)
view all 4 authors...
Abstract null null There are currently no vaccines or effective drugs to prevent the disorders caused by avian leukosis virus subgroup J (ALV-J). Hence, it is critical to identify potential biomarkers in ALV-J-infected chickens to prevent ALV-J-induced disorders. We hypothesized that ALV-J infection alters metabolic profile in chickens. In the present study, a nontargeted metabolomics approach based on liquid chromatography coupled with mass spectrometry (LC-MS) was used to find differential met...
Source
#1Yuan Chen (Huizhou University)
#2Hong-Wei Li (Huizhou University)
view all 4 authors...
Chicken is one of the economically important poultry species. Avian leucosis virus subgroup J (ALV-J) has emerged as a serious cause of mortality and suboptimal performance of domestic chickens. Changes in virome may contribute to pathogenesis. Thus, it is important to investigate the effects of ALV-J infection on the composition of the virome in chicken. In the study metagenomic sequencing was used to characterize the virome of feces collected from the AVL-J infected chickens and the controls. ...
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#1Houkun Wang (Yangtze University)
#2Xueyang Chen (Yangtze University)H-Index: 1
Last. Yang Yuying (Yangtze University)H-Index: 2
view all 10 authors...
ABSTRACT Avian leukosis virus subgroup J (ALV-J) is an avian oncogenic retrovirus that has caused huge economic losses in the poultry industry due to its great pathogenicity and transmission ability. However, the continuous emergence of new strains would bring challenges to diagnosis and control of ALV-J. .This study focuses on preparing the monoclonal antibody)MAb( against ALV-J Gp85 and identifying its epitope. The truncated ALV-J gp85 gene fragment was amplified and then cloned into expressio...
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#1Haiqin LiH-Index: 2
#2Tan MeifangH-Index: 1
Last. Kang ZhaofengH-Index: 1
view all 11 authors...
Avian leukosis caused by avian leukosis virus (ALV) is one of the most severe diseases endangering the poultry industry. When the eradication measures performed in commercial broilers and layers have achieved excellent results, ALV in some local chickens has gradually attracted attention. Since late 2018, following the re-outbreak of ALV-J in white feather broilers in China, AL-like symptoms also suddenly broke out in some local flocks, leading to great economic losses. In this study, a systemat...
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#1Moru Xu (YZU: Yangzhou University)H-Index: 2
#2Xiaohui MuH-Index: 1
Last. Aijian Qin (YZU: Yangzhou University)H-Index: 19
view all 9 authors...
Abstract Tibetan chickens are descendants of the ancestral red jungle fowl Gallus gallus. Very little is known about pathogens in Tibetan chickens living in the high-altitude environment. Here, we report for the first time the detection and isolation of avian leukosis virus from Tibetan chickens, with all the avian leukosis virus鈥損ositive samples belonging to subgroup J. Phylogenetic analysis of the sequence revealed these viruses were in a new branch compared with previous reports. The 3鈥-end o...
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#1Qiaomu Deng (Xida: Guangxi University)H-Index: 3
#2Min Li (Xida: Guangxi University)H-Index: 4
Last. Ping Wei (Xida: Guangxi University)H-Index: 11
view all 9 authors...
Avian leukosis virus subgroup J (ALV-J) has infected a variety of birds, causing major economic losses in China. Understanding the comprehensive criteria of classification and nomenclature of ALV-J would be useful for the investigation of the viral evolution and also for the prevention and control of this infection. An in-depth analysis of the genetic diversity of ALV-J was performed in the present study. Four hundred and seventy-five sequences of the gp85 gene, including thirteen of avian endog...
Source
#1Muhammad Farooque (Harbin Veterinary Research Institute)H-Index: 3
#2Xinyi Li (Harbin Veterinary Research Institute)H-Index: 3
Last. Yulong Gao (Harbin Veterinary Research Institute)H-Index: 25
view all 20 authors...
Since subgroup J avian leukosis virus (ALV-J) was first isolated in the United Kingdom in 1988, it has seriously hindered the development of the poultry industry worldwide. Although cases of ALV-J infection have been reported as early as 2001 in Pakistan, there was no further research on the isolation and molecular characteristics of ALVs. In the present study, we first isolated two ALVs from suspicious clinical samples that were collected from a desi chicken farm in Pakistan. The results of mul...
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#1Meige Ma (Harbin Veterinary Research Institute)H-Index: 1
#2Mengmeng Yu (Harbin Veterinary Research Institute)H-Index: 5
Last. Yulong Gao (Harbin Veterinary Research Institute)H-Index: 25
view all 20 authors...
Abstract Avian leukosis virus subgroup J (ALV-J) was first isolated from broiler chickens in China in 1999; subsequently, it was rapidly introduced into layer chickens and Chinese local chickens. Recently, the incidence of ALV-J in broiler and layer chickens has significantly decreased. However, it has caused substantial damage to Chinese local chickens, resulting in immense challenges to their production performance and breeding safety. To systematically analyze the molecular characteristics an...
Source
#1Xinheng Zhang (SCAU: South China Agricultural University)H-Index: 13
#2Zhihong Liao (SCAU: South China Agricultural University)H-Index: 2
Last. Qingmei Xie (SCAU: South China Agricultural University)H-Index: 25
view all 8 authors...
MicroRNAs (miRNAs/miRs) serve a key role in regulating the cell cycle and inducing tumorigenesis. Subgroup J of the avian leukosis virus (ALV-J) belongs to the family Retroviridae, subfamily Orthoretrovirinae and genus Alpharetrovirus that causes tumors in susceptible chickens. gga-miR-375 is downregulated and Yes-associated protein 1 (YAP1) is upregulated in ALV-J-induced tumors in the livers of chickens, and it has been further identified that YAP1 is the direct target gene of gga-miR-375. In ...
Source
#1Tuofan Li (YZU: Yangzhou University)H-Index: 8
#2Xiaohui Yao (YZU: Yangzhou University)H-Index: 2
Last. Jianqiang Ye (YZU: Yangzhou University)H-Index: 24
view all 14 authors...
Different from other subgroups of avian leukosis viruses (ALVs), ALV-J is highly pathogenic. It is the main culprit causing myeloid leukemia and hemangioma in chickens. The specialty of env gene of ALV-J with low homology to those of other ALVs is linked to its unique pathogenesis, but the underlying mechanism remains unclear. Previous studies show the env of ALV-J can be grouped into three species based on the tyrosine motifs in the cytoplasmic domain (CTD) of Gp37, i.e., the inhibitory, bi-fun...
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