Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice

The seeds of Clausena lansium have been used to treat acute and chronic gastro-intestinal disorders. To further explore its therapeutic value on metabolic diseases, a water soluble fraction from ethanolic extract of C. lansium seeds (HP) was evaluated on a high-fat diet (HFD) induced obesity mice model. The mice were fed with HFD for 8 weeks to induce obesity, and then orally administrated with HP for 9 weeks. The results showed HP treatment...