Roles of matrix metalloproteinases (MMPs) in SM-induced pathologies

Published on Jan 2, 2020in Toxin Reviews4.266
路 DOI :10.1080/15569543.2018.1477163
Ali Khamisabadi2
Estimated H-index: 2
(University of Tabriz),
Eisa Tahmasbpour12
Estimated H-index: 12
(Pasteur Institute of Iran)
+ 1 AuthorsAlireza Shahriary10
Estimated H-index: 10
(BMSU: Baqiyatallah University of Medical Sciences)
Sources
Abstract
AbstractDysregulation of matrix metalloproteinases (MMPs) is now considered as one of the main toxicity effects of sulfur mustard (SM). Numerous studies have found overexpression of MMPs, but the m...
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#1Alireza ShahriaryH-Index: 10
#2Yunes Panahi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 39
Last. Hossein RahmaniH-Index: 5
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INTRODUCTION: The chronic systemic inflammation is a result of releasing inflammatory cytokines from the cells relating to the body immunity system and chronic activation of the innate immunity system. AIM: To evaluate the relationship among serum levels of interleukin 6 (IL-6), interleukin 8 (IL-8), C-reactive protein (CRP) with forced expiratory volume in 1st s (FEV1) in patients with mustard lung (ML) and chronic obstructive pulmonary diseases (COPD). MATERIAL AND METHODS: A published literat...
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BACKGROUND: Matrix metalloproteinases (MMPs) are a family of proteinases and have the vigorous capacity to degrade all parts of the extracellular matrix. MMP enzymes strongly participate in physiological processes such as normal tissue remodeling and wound healing and in pathology of pulmonary diseases. They are released in response to environmental stimuli such as toxins and regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). Sulfur mustard (SM) is a chemical toxic which ca...
#1Amir Nejad-Moghaddam (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 4
#2Sohiela Ajdary (Pasteur Institute of Iran)H-Index: 1
Last. Mostafa Ghanei (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 40
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Oxidative stress and inflammation are one of the main pathological consequences of sulfur mustard on human lungs. Unfortunately, there is no effective treatment to mitigate pathological effects of sulfur mustard in mustard lungs. Here, we aimed to evaluate potential efficacy of systemic mesenchymal stem cells administration on expression of oxidative stress- and inflammation-related genes in sulfur mustard-exposed patients. Our patient received 100 million cells per injection, which was continue...
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#1Eisa Tahmasbpour (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 12
#2Mostafa Ghanei (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 40
Last. Yunes Panahi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 39
view all 5 authors...
Abstract Sulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung tissue. Although pathological effects of SM on mustard lung have been widely considered, molecular and cellular mechanisms for these pathologies are poorly understood. We investigated changes in expression of genes related to oxidative stress (OS) and antioxidant defense caused by SM in lung tissue of patients. We performed gene expression profiling of OS and antioxidant defense in lung tissue ...
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#1Agata Jab艂o艅ska-Trypu膰 (Bialystok University of Technology)H-Index: 9
#2Marzena Matejczyk (Bialystok University of Technology)H-Index: 7
Last. Stanis艂aw J贸zef Rosochacki (Bialystok University of Technology)H-Index: 4
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AbstractThe main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main structural component of connective tissue and its degradation is a very important process in the development, morphogenesis, tissue remodeling, and repair. Typical structure of MMPs consists of several distinct domains. MMP family can be divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, m...
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#1Xiannu Jin (WRAIR: Walter Reed Army Institute of Research)H-Index: 2
#2Radharaman RayH-Index: 19
Last. Prabhati Ray (WRAIR: Walter Reed Army Institute of Research)H-Index: 16
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Abstract Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we observed that SM stimulates several proteases and the epidermal-dermal attachment protein laminin-5 is one of the substrates. We propose that following SM exposure of the skin, laminin-5 degradation causes the detachment of the epidermi...
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#1G. M. KannanH-Index: 22
#2Pravin KumarH-Index: 11
Last. Kumaran Ganesan (DRDE: Defence Research and Development Establishment)H-Index: 17
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AbstractObjective: The present study was planned to investigate the prophylactic efficacy of S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07), against topically applied SM induced pulmonary toxicity in mouse. Materials and methods: Animals were pretreated with S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) (249.4鈥塵g/kg by oral gavage) 30 minutes before SM exposure. The SM (6.48鈥塵g/kg) was applied on hair clipped dorsocaudal region (percutaneous) of the animal. The animals were sacrific...
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#2Mohammad Hossein Boskabady (MUMS: Mashhad University of Medical Sciences)H-Index: 45
Last. Vahideh GhoraniH-Index: 9
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AbstractContext: Previous research has found relationships between sulfur mustard (SM) toxicity and its adverse effects.Objective: SM is highly toxic to the respiratory system, leading to hacking cough, rhinorrheachest tightness, acute pharyngitis and laryngitis, chronic bronchitis and lung fibrosis. In this review, based on the scientific literature, we provide an updated summary of information on SM exposures and their differences with asthma and COPD.Method: Information of this review was obt...
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#1Alireza Shahriary (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 10
#2Mir Hadi Seyedzadeh (Tehran University of Medical Sciences)H-Index: 4
Last. Jafar Salimian (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 15
view all 4 authors...
AbstractMustard lung is a major pulmonary complication in individuals exposed to sulfur mustard (SM) gas during the Iran鈥揑raq war. It shares common pathological and clinical features with some chronic inflammatory lung disorders, particularly chronic obstructive pulmonary disease (COPD). Airway remodeling, which is one of the main causes of lung dysfunction and the dominant phenomenon of chronic pulmonary diseases, is seen in the mustard lung. Among all mediators involved in the remodeling proce...
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#1Eisa TahmasbpourH-Index: 12
#2Seyed Reza EmamiH-Index: 1
Last. Yunes PanahiH-Index: 39
view all 4 authors...
AbstractSulfur mustard (SM) is a potent alkylating agent that targets several organs, especially lung tissue. Although pathological effects of SM have been widely considered, molecular and cellular mechanisms for these pathologies are not well understood, yet. General cellular and molecular events such as inflammation, DNA damage, cell membrane disintegrity, apoptosis and cell death were observed either in in vitro or in vivo models exposed to SM. However, it is not obvious that which specific m...
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Cited By2
Newest
#1Somaye Sadeghi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 2
#2Mahtab Tapak (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
Last. Nariman Mosaffa (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 13
view all 4 authors...
Abstract Despite many studies investigating the mechanism of Sulfur Mustard (SM) induced lung injury the underlying mechanism is still unclear. Inflammatory and subsequent fibroproliferative stages of SM-toxicity are based upon several highly-related series of events controlled by the immune system. The inhalation of SM gas variably affects different cell populations within the lungs. Various studies have shown the critical role of macrophages in triggering a pulmonary inflammatory response as w...
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#1Ali Mohammad Mohseni Majd (Shahed University)H-Index: 3
#2Mehdi Alikhani (Royan Institute)H-Index: 9
Last. Tooba Ghazanfari (Shahed University)H-Index: 22
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Abstract Background Despite more than 30聽years after utilization of sulfur mustard or bis (2-chloroethyl) sulfide (SM) by Iraqi troops against Iranian military members and civilians, there are a lot of reported delayed complications for the exposed people. Nonetheless, the molecular mechanism of action from this chemical warfare agent is not recognized yet. Material and method In this study, we employed two dimensional gel electrophoresis (2DE) technique to investigate the serum proteins from ch...
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