Impact of antibiotic administration on blood culture positivity at the beginning of sepsis: a prospective clinical cohort study

Sepsis guidelines recommend obtaining blood cultures before starting anti-infective therapy in patients with sepsis. However, little is known of how antibiotic treatment before sampling affects bacterial growth. The aim of this study was to compare the results of blood cultures drawn before and during antibiotic therapy.Prospective clinical cohort study of septic patients. Adult intensive care unit patients with two or three blood culture sets...