Internal medicine

Renal cell carcinoma

Urology

Oncology

Kidney

Nephrectomy

Sunitinib

Medicine

New England Journal of Medicine

Cytoreductive nephrectomy has been the standard of care in metastatic renal-cell carcinoma for 20 years, supported by randomized trials and large, retrospective studies. However, the efficacy of targeted therapies has challenged this standard. We assessed the role of nephrectomy in patients with metastatic renal-cell carcinoma who were receiving targeted therapies.

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma