The reverse remodeling response to sacubitril/valsartan therapy in heart failure with reduced ejection fraction

Summary Background Major classes of medical therapy for heart failure with reduced ejection fraction (HFrEF) induce reverse remodeling. The revere remodeling response to sacubitril/valsartan remains unstudied. Methods We performed a single‐center, prospective assessor‐blinded study to determine the reverse remodeling response of sacubitril/valsartan therapy in HFrEF patients with a class I indication (New York heart Association [ NYHA ]‐class II...