Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers
Abstract
Of the three RAS oncoproteins, only HRAS is delocalized and inactivated by farnesyltransferase inhibitors (FTI), an approach yet to be exploited clinically. In this study, we treat mice bearing Hras-driven poorly differentiated and anaplastic thyroid cancers (Tpo-Cre/HrasG12V/p53flox/flox) with the FTI tipifarnib. Treatment caused sustained tumor regression and increased survival; however, early and late resistance was observed. Adaptive...
Paper Details
Title
Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers
Published Date
Aug 14, 2018
Journal
Volume
78
Issue
16
Pages
4642 - 4657
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