Endogenous GLP‐1 alters postprandial functional connectivity between homeostatic and reward‐related brain regions involved in regulation of appetite in healthy lean males: A pilotstudy

Aims Peripheral infusion of glucagon‐like peptide‐1 (GLP‐1) can affect brain activity in areas involved in the regulation of appetite, including hypothalamic and reward‐related brain regions. In contrast, the physiological role of endogenous GLP‐1 in the central regulation of appetite has hardly been investigated. Materials and Methods This was a randomized, cross‐over trial that involved 12 healthy volunteers who received an intragastric (ig)...