Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes
Abstract
Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of collagen-degrading collagenases such as matrix metalloproteinase 1 (MMP1) and MMP13 in human articular chondrocytes. Indeed, joint diseases with an inflammatory component are characterised by excessive extracellular matrix (ECM) catabolism. Importantly, protein kinase C (PKC) signalling has a primary...
Paper Details
Title
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes
Published Date
Apr 13, 2018
Journal
Volume
13
Issue
4
Pages
e0195864 - e0195864
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