Review paper

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Volume: 37, Issue: 1
Published: Apr 27, 2018
Abstract
Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to be associated with tumor angiogenesis, tumor cell migration and proliferation, and metastasis. Integrins, especially αvβ3, αvβ5 and α5β1, participate in mediating tumor angiogenesis by interacting with the vascular endothelial growth factor and angiopoietin-Tie signaling...
Paper Details
Title
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
Published Date
Apr 27, 2018
Volume
37
Issue
1
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