VEGFR Recognition Interface of a Proangiogenic VEGF‐Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy

QK peptide is a vascular endothelial growth factor (VEGF)-mimetic molecule with significant proangiogenic activity. In particular, QK is able to bind and activate VEGF receptors (VEGFRs) to stimulate a functional response in endothelial cells. To characterize the peptide bioactivity and its molecular recognition properties, a detailed picture of the interaction between peptide QK and VEGF receptors is reported. By combining NMR spectroscopy...