Immune Factors in Deep Vein Thrombosis Initiation

Local endothelial activation, and the release of Weibel–Palade bodies present in endothelial cells, are instrumental for deep vein thrombosis (DVT) initiation. In addition to the vascular system, the immune system is emerging as a pivotal player in the pathophysiology of DVT, potentially opening new prophylactic approaches. Mast cell activation and degranulation are crucial for the local inflammatory response resulting in DVT. Mast cells may...