PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs
Abstract
Widespread mRNA decay, an unappreciated feature of apoptosis, enhances cell death and depends on mitochondrial outer membrane permeabilization (MOMP), TUTases, and DIS3L2. Which RNAs are decayed and the decay-initiating event are unknown. Here, we show extensive decay of mRNAs and poly(A) noncoding (nc)RNAs at the 3' end, triggered by the mitochondrial intermembrane space 3'-to-5' exoribonuclease PNPT1, released during MOMP. PNPT1 knockdown...
Paper Details
Title
PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs
Published Date
Jun 1, 2018
Journal
Volume
174
Issue
1
Pages
187 - 201.e12
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