RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

Yoshihide Mitsuda; Ken Morita; Gengo Kashiwazaki; Junichi Taniguchi; Toshikazu Bando; Moeka Obara; Masahiro Hirata; Tatsuki R. Kataoka; Manabu Muto; Yasufumi Kaneda; Hiroshi Sugiyama; Yasuhiko Kamikubo

doi:https://doi.org/10.1038/s41598-018-24969-w

doi.org/10.1038/s41598-018-24969-w

RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

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..., Yasuhiko Kamikubo

17

Scientific Reports4.60

Volume: 8, Issue: 1

Published: Apr 23, 2018

Abstract

The dual function of runt-related transcriptional factor 1 (RUNX1) as an oncogene or oncosuppressor has been extensively studied in various malignancies, yet its role in gastric cancer remains elusive. Up-regulation of the ErbB2/HER2 signaling pathway is frequently-encountered in gastric cancer and contributes to the maintenance of these cancer cells. This signaling cascade is partly mediated by son of sevenless homolog (SOS) family, which...

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Paper Details

Title

RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells

DOI

doi.org/10.1038/s41598-018-24969-w

Published Date

Apr 23, 2018

Journal

Scientific Reports

Volume

8

Issue

1

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