Novel Richter Syndrome Xenograft Models to Study Genetic Architecture, Biology, and Therapy Responses
Abstract
Richter syndrome represents the evolution of chronic lymphocytic leukemia into an aggressive tumor, most commonly diffuse large B-cell lymphoma. The lack of in vitro and in vivo models has severely hampered drug testing in a disease that is poorly responsive to common chemoimmunotherapeutic combinations as well as to novel kinase inhibitors. Here we report for the first time the establishment and genomic characterization of two patient-derived...
Paper Details
Title
Novel Richter Syndrome Xenograft Models to Study Genetic Architecture, Biology, and Therapy Responses
Published Date
Jul 1, 2018
Journal
Volume
78
Issue
13
Pages
3413 - 3420
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Notes
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