Separation and determination of cinchona alkaloids by ligand-exchange capillary electrophoresis using a Cu(II)– l -lysine complex as selector

Volume: 15, Issue: 7, Pages: 1477 - 1483
Published: Apr 24, 2018
Abstract
The purpose of this study was to develop a novel, simple and precise ligand-exchange capillary electrophoresis method to separate the diastereomer pairs of four major cinchona alkaloids (quinine/quinidine and cinchonine/cinchonidine). The l-lysine and copper(II) were chosen as the ligand and the central ion, respectively. Optimal separation conditions of four alkaloids were 4.0 mM l-lys, 2.0 mM copper(II) and 30 mM NH4Ac at pH 8.9 and a applied...
Paper Details
Title
Separation and determination of cinchona alkaloids by ligand-exchange capillary electrophoresis using a Cu(II)– l -lysine complex as selector
DOI
Published Date
Apr 24, 2018
Journal
Volume
15
Issue
7
Pages
1477 - 1483
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