Update on Tumor Neoantigens and Their Utility: Why It Is Good to Be Different

Neoantigens are antigens generated by somatic mutations that can be recognized by the host immune system. Neoantigens in tumors can be targeted by T cells. Neoantigens can be identified and used in cancer therapies, such as cancer vaccines. Antitumor rejection by the immune system is a complex process that is regulated by several factors. Among these factors are the quality and quantity of mutational events that occur in cancer cells. Perhaps...