Self-nanoemulsifying drug delivery system of nabumetone improved its oral bioavailability and anti-inflammatory effects in rat model

The present research work explored the prospective of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of NBT and its anti-inflammatory effect. Nabumetone (NBT) is a poorly aqueous soluble drug that demonstrates low bioavailability after oral administration. NBT-SNEDDS was prepared by using Capryol-90, Tween-80 and polyethylene glycol-400 (PEG-400) via pseudo-ternary phase diagram. Different components of...