Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control
Abstract
To study and elucidate the effect of the intensity and duration of processing stresses on the possible solid-state changes during a hot melt extrusion granulation process. Blends of α-indomethacin and PEG 3350 (w/w 4:1) were granulated using various screw sizes/designs on the melt extruder under different temperature regimes. Differential Scanning Calorimetry and X-ray Powder Diffraction were employed for characterization. The dissolution...
Paper Details
Title
Polymorphic Transformation of Indomethacin during Hot Melt Extrusion Granulation: Process and Dissolution Control
Published Date
May 10, 2018
Journal
Volume
35
Issue
7
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