Subthreshold Amyloid Predicts Tau Deposition in Aging

Current approaches to the early detection of Alzheimer's disease (AD) rely upon classifying individuals as “positive” or “negative” for biomarkers related to the core pathology of β-amyloid (Aβ). However, the accumulation of Aβ begins slowly, years before biomarkers become abnormal. We used longitudinal [ 11 C] Pittsburgh Compound B PET scanning and neuropsychological assessment to investigate the earliest changes in AD pathology and how it...