Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

Volume: 128, Issue: 6, Pages: 2356 - 2369
Published: Jun 1, 2018
Abstract
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tumor cells with CRISPR-based deletion of Pros1 failed to inhibit M1 polarization. Tumor cell-associated Pros1 action was abrogated in macrophages from Mer- and Tyro3- but not Axl-KO mice. In addition,...
Paper Details
Title
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response
Published Date
Jun 1, 2018
Volume
128
Issue
6
Pages
2356 - 2369
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