Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids
Abstract
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for their translation and self-replication, without infectious progeny generation, providing high levels of antigen expression for inducing humoral and cellular immunity. Synthetic nanoparticle-based...
Paper Details
Title
Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids
Published Date
Sep 1, 2018
Volume
12
Pages
118 - 134
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