Unconventional mechanisms of eukaryotic protein secretion

A big surprise in the molecular cell biology of eukaryotes has been the discovery of pathways of protein secretion that are not linked to the endoplasmic reticulum (ER) and the Golgi apparatus. Various kinds of unconventional secretory processes have been described, including two major pathways for two distinct sets of cargoes that are initially synthesized as soluble proteins in the cytoplasm. These two pathways are mechanistically distinct...