Original paper

Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma

Volume: 171, Pages: 230 - 246
Published: Jul 1, 2018
Abstract
Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, we tissue-engineered a novel orthotopic humanized bone model.Orthotopic humanized tissue engineered bone constructs (ohTEBC) were fabricated by 3D printing of medical-grade polycaprolactone scaffolds, which were seeded with human osteoblasts...
Paper Details
Title
Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma
Published Date
Jul 1, 2018
Volume
171
Pages
230 - 246
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.