The Brockenbrough-Braunwald-Morrow sign.

Published on Apr 30, 2018in The Journal of Thoracic and Cardiovascular Surgery4.451
· DOI :10.1016/J.JTCVS.2018.04.095
Hao Cui4
Estimated H-index: 4
(Mayo Clinic),
Anita Nguyen10
Estimated H-index: 10
(Mayo Clinic),
Hartzell V. Schaff131
Estimated H-index: 131
(Mayo Clinic)
#1Rick A. Nishimura (Mayo Clinic)H-Index: 128
#2Hubert Seggewiss (Mayo Clinic)H-Index: 1
Last. Hartzell V. Schaff (Mayo Clinic)H-Index: 131
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Hypertrophic cardiomyopathy is a genetic disorder characterized by marked hypertrophy of the myocardium. It is frequently accompanied by dynamic left ventricular outflow tract obstruction and symptoms of dyspnea, angina, and syncope. The initial therapy for symptomatic patients with obstruction is medical therapy with β-blockers and calcium antagonists. However, there remain a subset of patients who have continued severe symptoms, which are unresponsive to medical therapy. These patients can be ...
58 CitationsSource
#1Elena Ashikhmina (Mayo Clinic)H-Index: 8
#2Hartzell V. Schaff (Mayo Clinic)H-Index: 131
Last. Martin D. Abel (Mayo Clinic)H-Index: 42
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Objectives We sought to summarize our recent experience with intraoperative monitoring for management of patients undergoing surgical myectomy for hypertrophic obstructive cardiomyopathy with emphasis on dynamic left ventricular outflow tract obstruction. We also analyzed the impact of these data on surgical decision-making and adequacy of septal myectomy. Methods We retrospectively analyzed the medical records of 198 patients who underwent transaortic septal myectomy and evaluated baseline and ...
43 CitationsSource
#1M W Cooper (University of Texas Health Science Center at Tyler)H-Index: 1
Postextrasystolic potentiation (PESP), the increase in contractility that follows an extrasystole, is an interesting phenomenon that has been known for almost 100 years. The literature on this effect is reviewed. It is found that there is significant evidence that the phenomenon is independent of muscle loading and represents a distinct property of the myocardium. Examination of the literature pertaining to the cause of the effect suggests that calcium shifts within the sarcoplasmic reticulum ar...
92 CitationsSource
#1Edwin C. Brockenbrough (NIH: National Institutes of Health)H-Index: 10
#2Eugene Braunwald (NIH: National Institutes of Health)H-Index: 266
Last. Andrew G. Morrow (NIH: National Institutes of Health)H-Index: 84
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In the presence of valvular aortic stenosis or of discrete subvalvular stenosis, the narrowed orifice is constant and its size is not altered by changes in the force of ventricular contraction. In hypertrophic subaortic stenosis the orifice narrows during systolic contraction of the hypertrophied muscle in the left ventricular outflow tract and the orifice size therefore is a function of the force of left ventricular contraction. In 75 patients, proved to have the discrete, "fixed" type of aorti...
193 CitationsSource
Cited By2
#1Juliano Lentz Carvalho (Mayo Clinic)H-Index: 3
#2Elena Ashikhmina (Mayo Clinic)H-Index: 8
Last. Hartzell V. Schaff (Mayo Clinic)H-Index: 131
view all 7 authors...
OBJECTIVES It is not uncommon to observe some discrepancy in hemodynamic values characterizing left ventricular outflow tract (LVOT) obstruction preoperatively and in the operating room in patients with hypertrophic obstructive cardiomyopathy. Interpretation of this discrepancy can be challenging. To clarify the extent of the discrepancy, the authors compared hemodynamic variables in patients undergoing septal myectomy at the time of preoperative and intraoperative evaluation. DESIGN Retrospecti...