Original paper

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Volume: 70, Issue: 4, Pages: 707 - 721.e7
Published: May 1, 2018
Abstract
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε complex, leading to embryonic lethality in inbred strains and extensive developmental abnormalities, leukopenia, and tumor predisposition in outbred...
Paper Details
Title
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
Published Date
May 1, 2018
Volume
70
Issue
4
Pages
707 - 721.e7
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