A microengineered human corneal epithelium-on-a-chip for eye drops mass transport evaluation
Abstract
Animals are commonly used for pharmacokinetic studies which are the most frequent events tested during ocular drug development and preclinical evaluation. Inaccuracy, cost, and ethical criticism in these tests have created a need to construct an in vitro model for studying corneal constraints. In this work, a porous membrane embedded microfluidic platform is fabricated that separates a chip into an apical and basal side. After functionalizing...
Paper Details
Title
A microengineered human corneal epithelium-on-a-chip for eye drops mass transport evaluation
Published Date
Jan 1, 2018
Journal
Volume
18
Issue
11
Pages
1539 - 1551
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Notes
History