Tumor cells

Tropism

Tumor microenvironment

Cancer

Osteosarcoma

Stem cell

Cell biology

Virus

Carcinogenesis

Biology

Internal medicine

Mesenchymal stem cell

Immunology

Medicine

Metastasis

Cancer research

Stem Cell Research & Therapy

During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborated to mediate proliferation, metastasis, and drug resistance in many cancers, including osteosarcoma. What's more, because of tumor site tropism, MSCs can be engineered to be loaded with therapeutic agents so that drugs can be precisely delivered to tumor lesions. In this review, we mainly discuss recent advances concerning the functions of MSCs in osteosarcoma and their possible clinical applications in the future.

Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications