Immunogenicity testing of therapeutic antibodies in ocular fluids after intravitreal injection
Abstract
Aim: High drug concentrations in ocular fluids after intravitreal administration preclude the use of drug-sensitive immunoassays. A drug-tolerant immunoassay is therefore desirable for immunogenicity testing in ophthalmology. Experimental: Immune complex (IC) antidrug antibody (ADA) assays were established for two species. The assays were compared with the bridging assay in ocular and plasma samples from two preclinical studies. Results: The IC...
Paper Details
Title
Immunogenicity testing of therapeutic antibodies in ocular fluids after intravitreal injection
Published Date
Jun 1, 2018
Journal
Volume
10
Issue
11
Pages
803 - 814
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